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We, the scientists at the Institute of Microbiology aim to perform groundbreaking research into how multicellular organisms protect themselves against infections and how the commensal microbiota has established a mutualistic relationship with its host at border surfaces. An interesting theme has become research into the molecular and epigenetic mechanisms of host adaptation to a rapidly changing environment, a process often mediated by components of the innate immune system. We are eager to open new frontiers for research and approach unresolved issues in biology. Such new insights should fundamentally change our scientific thinking and may substantially contribute to future medical practice through the development of more efficient treatment methods to find cure for debilitating diseases such as infections, cancer and inflammatory syndromes.